In the context of nutrition, a mineral is a chemical element. Some "minerals" are essential for life, but most are not.[1][2][3] Minerals are one of the four groups of essential nutrients; the others are vitamins, essential fatty acids, and essential amino acids.[4] The five major minerals in the human body are calcium, phosphorus, potassium, sodium, and magnesium.[2] The remaining minerals are called "trace elements". The generally accepted trace elements are iron, chlorine, cobalt, copper, zinc, manganese, molybdenum, iodine, selenium,[5] and bromine;[6] there is some evidence that there may be more.
The four organogenic elements, namely carbon, hydrogen, oxygen, and nitrogen (CHON), that comprise roughly 96% of the human body by weight,[7] are usually not considered as minerals (nutrient). In fact, in nutrition, the term "mineral" refers more generally to all the other functional and structural elements found in living organisms.
Plants obtain minerals from soil.[8] Animals ingest plants, thus moving minerals up the food chain. Larger organisms may also consume soil (geophagia) or use mineral resources such as salt licks to obtain minerals.
Finally, although mineral and elements are in many ways synonymous, minerals are only bioailable to the extent that they can be absorbed. To be absorbed, minerals either must be soluble or readily extractable by the consuming organism. For example, molybdenum is an essential mineral, but metallic molybdenum has no nutritional benefit. Many molybdates are sources of molybdenum.
Essential chemical elements for humans[edit] Main article: Composition of the human bodyTwenty chemical elements are known to be required to support human biochemical processes by serving structural and functional roles, and there is evidence for a few more.[1][9]
Oxygen, hydrogen, carbon and nitrogen are the most abundant elements in the body by weight and make up about 96% of the weight of a human body. Calcium makes up 920 to 1200 grams of adult body weight, with 99% of it contained in bones and teeth. This is about 1.5% of body weight.[2] Phosphorus occurs in amounts of about 2/3 of calcium, and makes up about 1% of a person's body weight.[10] The other major minerals (potassium, sodium, chlorine, sulfur and magnesium) make up only about 0.85% of the weight of the body. Together these eleven chemical elements (H, C, N, O, Ca, P, K, Na, Cl, S, Mg) make up 99.85% of the body. The remaining ≈18 ultratrace minerals comprise just 0.15% of the body, or about one hundred grams in total for the erage person. Total fractions in this paragraph are amounts based on summing percentages from the article on chemical composition of the human body.
Some diversity of opinion exist about the essential nature of various ultratrace elements in humans (and other mammals), even based on the same data. For example, whether chromium is essential in humans is debated. No Cr-containing biochemical has been purified. The United States and Japan designate chromium as an essential nutrient,[11][12] but the European Food Safety Authority (EFSA), representing the European Union, reviewed the question in 2014 and does not agree.[13]
Most of the known and suggested mineral nutrients are of relatively low atomic weight, and are reasonably common on land, or for sodium and iodine, in the ocean. They also tend to he soluble compounds at physiological pH ranges: elements without such soluble compounds tend to be either non-essential (Al) or, at best, may only be needed in traces (Si).[1]
Essential elements for higher organisms (eucarya).[14][15][16][17][1][6][18] vte H He Li Be B C N O F Ne Na Mg Al Si P S Cl Ar K Ca Sc Ti V Cr Mn Fe Co Ni Cu Zn Ga Ge As Se Br Kr Rb Sr Y Zr Nb Mo Tc Ru Rh Pd Ag Cd In Sn Sb Te I Xe Cs Ba Lu Hf Ta W Re Os Ir Pt Au Hg Tl Pb Bi Po At Rn Legend: The four basic organic elements Quantity elements Essential trace elements Essentiality or function debated Not essential in humans, but essential/beneficial for some non-human eucarya Roles in biological processes[edit] Dietary element RDA/AI male/female (US) [mg][19] UL (US and EU) [mg][19][20] Category High nutrient density dietary sources Terms for deficiency/excess Potassium 4700 NE; NE A systemic electrolyte and is essential in coregulating ATP with sodium Sweet potato, tomato, potato, beans, lentils, dairy products, seafood, banana, prune, carrot, orange[21] hypokalemia / hyperkalemia Chlorine 2300 3600; NE Needed for production of hydrochloric acid in the stomach, in cellular pump functions and required in host defense Table salt (sodium chloride) is the main dietary source. hypochloremia / hyperchloremia Sodium 1500 2300; NE A systemic electrolyte and is essential in coregulating ATP with potassium Table salt (sodium chloride, the main source), sea vegetables, milk, and spinach. hyponatremia / hypernatremia Calcium 1000 2500; 2500 Needed for muscle, heart and digestive system health, builds bone (see hydroxyapatite), supports synthesis and function of blood cells, helps in blood clotting Dairy products, eggs, canned fish with bones (salmon, sardines), green leafy vegetables, nuts, seeds, tofu, thyme, oregano, dill, cinnamon.[22] hypocalcaemia / hypercalcaemia Phosphorus 700 4000; 4000 A component of bones (see hydroxyapatite), cells, in energy processing, in DNA and ATP (as phosphate) and many other functions Red meat, dairy foods, fish, poultry, bread, rice, oats.[23][24] In biological contexts, usually seen as phosphate[25] hypophosphatemia / hyperphosphatemia Magnesium 420/320 350; 250 Required for processing ATP and for bones Spinach, legumes, nuts, seeds, whole grains, peanut butter, ocado[26] hypomagnesemia (magnesium deficiency) / hypermagnesemia Iron 8/18 45; NE Required for many proteins and enzymes, notably hemoglobin to prevent anemia Meat, seafood, nuts, beans, dark chocolate[27] iron deficiency / iron overload disorder Zinc 11/8 40; 25 Required for several classes of enzymes such as matrix metalloproteinases, liver alcohol dehydrogenase, carbonic anhydrase and zinc finger proteins Oysters*, red meat, poultry, nuts, whole grains, dairy products[28] zinc deficiency / zinc toxicity Manganese 2.3/1.8 11; NE Required co-factor for superoxide dismutase Grains, legumes, seeds, nuts, leafy vegetables, tea, coffee[29] manganese deficiency / manganism Copper 0.9 10; 5 Required co-factor for cytochrome c oxidase Liver, seafood, oysters, nuts, seeds; some: whole grains, legumes[29] copper deficiency / copper toxicity Iodine 0.150 1.1; 0.6 Required for the synthesis of thyroid hormones and to help enzymes in host defense Seaweed (kelp or kombu)*, grains, eggs, iodized salt[30] iodine deficiency (goiter) / iodism (hyperthyroidism[31]) Molybdenum 0.045 2; 0.6 Required for the functioning of xanthine oxidase, aldehyde oxidase, and sulfite oxidase[32] Legumes, whole grains, nuts[29] molybdenum deficiency / molybdenum toxicity[33] Selenium 0.055 0.4; 0.3 Essential to activity of antioxidant enzymes like glutathione peroxidase Brazil nuts, seafoods, organ meats, meats, grains, dairy products, eggs[34] selenium deficiency / selenosis Cobalt NE (trace); NE (trace) NE; NE Cobalt (as vitamin B12) is required for the synthesis of DNA, erythropoiesis (red blood cell formation), and the development, myelination, and function of the central nervous system. It is ailable for use by animals only after hing been processed by bacteria. Humans contain only milligrams of cobalt in these cofactors[35] Animal muscle and liver are good dietary sources, also shellfish and crab meat[36] pernicious anemia / cobalt poisoning Sulfur NE (abundant); NE (abundant) NE; NE Sulfur (as essential amino acid methionine and its derivative cysteine) is required for the synthesis of proteins, antioxidation, and the transcription, epigenetic expression, and gene regulation of DNA. It is unusual in that it is a mineral that may be taken in both inorganic and organic combinations. Sulfur is the most abundant mineral found in our body after calcium and phosphorus[37] Nuts, legumes, meats, eggs, fish, seafood, also fermented foods[38] compromised glutathione synthesis[37] / hyperhomocysteinemia Bromine NE (trace); NE (trace) NE; NE Important to basement membrane architecture and tissue development, as a needed catalyst to make collagen IV[6][17] bromismRDA = Recommended Dietary Allowance; AI = Adequate intake; UL = Tolerable upper intake level; Figures shown are for adults age 31–50, male or female neither pregnant nor lactating
* One serving of seaweed exceeds the US UL of 1100 μg but not the 3000 μg UL set by Japan.[39]
Dietary nutrition[edit]Dietitians may recommend that minerals are best supplied by ingesting specific foods rich with the chemical element(s) of interest. The elements may be naturally present in the food (e.g., calcium in dairy milk) or added to the food (e.g., orange juice fortified with calcium; iodized salt fortified with iodine). Dietary supplements can be formulated to contain several different chemical elements (as compounds), a combination of vitamins and/or other chemical compounds, or a single element (as a compound or mixture of compounds), such as calcium (calcium carbonate, calcium citrate) or magnesium (magnesium oxide), or iron (ferrous sulfate, iron bis-glycinate).[citation needed]
The dietary focus on chemical elements derives from an interest in supporting the biochemical reactions of metabolism with the required elemental components.[40] Appropriate intake levels of certain chemical elements he been demonstrated to be required to maintain optimal health. Diet can meet all the body's chemical element requirements, although supplements can be used when some recommendations are not adequately met by the diet. An example would be a diet low in dairy products, and hence not meeting the recommendation for calcium.
Plants[edit] Structure of the Mn4O5Ca core of the oxygen-evolving site in plants, illustrating one of many roles of the trace mineral manganese.[41]The list of minerals required for plants is similar to that for animals. Both use very similar enzymes, although differences exist. For example, legumes host molybdenum-containing nitrogenase, but animals do not. Many animals rely on hemoglobin (Fe) for oxygen transport, but plants do not. Fertilizers are often tailored to address mineral deficiencies in particular soils. Examples include molybdenum deficiency, manganese deficiency, zinc deficiency, and so on.
Safety[edit]The gap between recommended daily intake and what are considered safe upper limits (ULs) can be small. For example, for calcium the U.S. Food and Drug Administration set the recommended intake for adults over 70 years at 1,200 mg/day and the UL at 2,000 mg/day.[19] The European Union also sets recommended amounts and upper limits, which are not always in accord with the U.S.[20] Likewise, Japan, which sets the UL for iodine at 3000 μg versus 1100 for the U.S. and 600 for the EU.[39] In the table above, magnesium appears to be an anomaly as the recommended intake for adult men is 420 mg/day (women 350 mg/day) while the UL is lower than the recommended, at 350 mg. The reason is that the UL is specific to consuming more than 350 mg of magnesium all at once, in the form of a dietary supplement, as this may cause diarrhea. Magnesium-rich foods do not cause this problem.[42]
Elements considered possibly essential for humans but not confirmed[edit]Many ultratrace elements he been suggested as essential, but such claims he usually not been confirmed. Definitive evidence for efficacy comes from the characterization of a biomolecule containing the element with an identifiable and testable function.[5] One problem with identifying efficacy is that some elements are innocuous at low concentrations and are pervasive (examples: silicon and nickel in solid and dust), so proof of efficacy is lacking because deficiencies are difficult to reproduce.[40] Some elements were once thought to he a role with unknown biochemical nature, but the evidence has not always been strong.[5] For example, it was once thought that arsenic was probably essential in mammals,[43] but it seems to be only used by microbes;[6] and while chromium was long thought to be an essential trace element based on rodent models, and was proposed to be involved in glucose and lipid metabolism,[44][45] more recent studies he conclusively ruled this possibility out. It may still he a role in insulin signalling, but the evidence is not clear, and it only seems to occur at doses not found in normal diets.[6] Boron is essential to plants,[46][47][48] but not animals.[6]
Non-essential elements can sometimes appear in the body when they are chemically similar to essential elements (e.g. Rb+ and Cs+ replacing Na+), so that essentiality is not the same thing as uptake by a biological system.[1]
Element Description Excess Nickel Nickel is an essential component of several enzymes, including urease and hydrogenase.[49] Although not required by humans, some are thought to be required by gut bacteria, such as urease required by some varieties of Bifidobacterium.[50] In humans, nickel may be a cofactor or structural component of certain metalloenzymes involved in hydrolysis, redox reactions and gene expression. Nickel deficiency depressed growth in goats, pigs, and sheep, and diminished circulating thyroid hormone concentration in rats.[51] Nickel toxicity Fluorine There is no evidence that fluorine is essential, but it is beneficial.[6][52] Research indicates that the primary dental benefit from fluoride occurs at the surface from topical exposure.[53][54] Of the minerals in this table, fluoride is the only one for which the U.S. Institute of Medicine has established an Adequate Intake.[55] Fluoride poisoning Lithium Based on plasma lithium concentrations, biological activity and epidemiological observations, there is evidence, not conclusive, that lithium is an essential nutrient.[15][16] Lithium toxicity Silicon Silicon is beneficial to most plants, but usually not essential. It seems to he beneficial effects in humans, strengthening bones and connective tissue, but these effects are still being studied. In any case deficiency symptoms do not arise because silicon occurs significantly in food made from plants.[6] Vanadium Has an established, albeit specialized, biochemical role in other organisms (algae, lichens, fungi, bacteria), and there is significant circumstantial evidence for its essentiality in humans. It is rather toxic for a trace element and the requirement, if essential, is probably small.[52] Other There are several elements that are not used by mammals, but seem to be beneficial in other organisms: boron, aluminium, titanium, arsenic, rubidium, strontium, cadmium, antimony, tellurium, barium, the early lanthanides (from lanthanum to gadolinium), tungsten, and uranium. (In the cases of Al and Rb the mechanism is not well understood.) In particular, B, Ti, Sr, Cd, and Ba are used by eukaryotes, and Al and Rb might be as well.[6][52] Mineral ecology[edit] Further information: BiomineralizationDiverse ions are used by animals and microorganisms for the process of mineralizing structures, called biomineralization, used to construct bones, seashells, eggshells,[56] exoskeletons and mollusc shells.[57][citation needed]
Minerals can be bioengineered by bacteria which act on metals to catalyze mineral dissolution and precipitation.[58] Mineral nutrients are recycled by bacteria distributed throughout soils, oceans, freshwater, groundwater, and glacier meltwater systems worldwide.[58][59] Bacteria absorb dissolved organic matter containing minerals as they scenge phytoplankton blooms.[59] Mineral nutrients cycle through this marine food chain, from bacteria and phytoplankton to flagellates and zooplankton, which are then eaten by other marine life.[58][59] In terrestrial ecosystems, fungi he similar roles as bacteria, mobilizing minerals from matter inaccessible by other organisms, then transporting the acquired nutrients to local ecosystems.[60][61]
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Berlin: Springer. pp. 287–300. ISBN 978-3-540-71840-6. ^ Gadd GM (January 2017). "The Geomycology of Elemental Cycling and Transformations in the Environment" (PDF). Microbiol Spectr. 5 (1) 5.1.09: 371–386. doi:10.1128/microbiolspec.FUNK-0010-2016. ISBN 978-1-55581-957-6. PMC 11687428. PMID 28128071. S2CID 4704240. Further reading[edit] Humphrey Bowen (1979) Environmental Chemistry of the Elements. Academic Press, ISBN 0-12-120450-2. Humphry Bowen (1966) Trace Elements in Biochemistry. Academic Press. External links[edit] Wikimedia Commons has media related to Dietary minerals. "Vitamins and minerals". nhs.uk. 23 October 2017. Concept of a nutritious food: toward a nutrient density score Metals in Nutrition vteFood chemistry Additives Carbohydrates Coloring Enzymes Essential fatty acids Flors Fortification Lipids "Minerals" (Chemical elements) Proteins Vitamins Water vteDietary supplementsTypes Bodybuilding supplement Energy drink Energy bar Fatty acids Herbal supplements Minerals Prebiotics Probiotics (Lactobacillus Bifidobacterium) Protein supplements Vitamins Vitamins andchemical elements ("minerals") Retinol (Vitamin A) B vitamins Thiamine (B1) Riboflin (B2) Niacin (B3) Pantothenic acid (B5) Pyridoxine (B6) Biotin (B7) Folic acid (B9) Cyanocobalamin (B12) Ascorbic acid (Vitamin C) Ergocalciferol and Cholecalciferol (Vitamin D) Tocopherol (Vitamin E) Naphthoquinone (Vitamin K) Calcium Choline Chromium Cobalt Copper Fluorine Iodine Iron Magnesium Manganese Molybdenum Phosphorus Potassium Selenium Sodium Sulfur Zinc Other common ingredients AAKG β-hydroxy β-methylbutyrate Carnitine Chondroitin sulfate Cod liver oil Copper gluconate Creatine Dietary fiber Echinacea Ephedra Fish oil Folic acid Ginseng Glucosamine Glutamine Grape seed extract Guarana Iron supplements Japanese honeysuckle Krill oil Lingzhi Linseed oil Lipoic acid Milk thistle Melatonin Red yeast rice Royal jelly Saw palmetto Spirulina St John's wort Taurine Wheatgrass Wolfberry Yohimbine Zinc gluconate Related articles Codex Alimentarius Enzyte Hadacol Herbal tea Nutraceutical Multivitamin Nutrition vteMineral supplements (A12)MajorCalcium# β-hydroxy-β-methylbutyrate acetate ascorbate carbonate chloride +cholecalciferol citrate folinate# glubionate glucoheptonate gluconate# glycerylphosphate lactate gluconate lactate malate pangamate phosphate sulfate hydroxyapatite Magnesium ascorbate aspartate carbonate chloride citrate gluconate glycinate lactate levulinate malate orotate oxide pidolate sulfate# taurate L-threonate Phosphorus adenosine triphosphate disodium hydroxyapatite monosodium phosphate Potassium ascorbate bicarbonate bitartrate carbonate chloride# citrate (+hydrogen carbonate) gluconate iodide# lactate malate permanganate# phosphate sulfate Sodium Docusate sodium# Glucose with sodium chloride# Heparin sodium# ascorbate calcium edetate# carbonate chloride# citrate gluconate hydrogen carbonate# lactate# malate nitrite# nitroprusside# phosphates stibogluconate# sulfate thiosulfate# Suramin sodium# Valproic acid# Sulfur barium sulfate# Calcium sulfate L-cysteine L-cystine L-glutathione Iron(II) sulfate# sulfate# L-methionine methylsulfonylmethane N-acetyl-L-cysteine R-α-lipoic acid potassium sulfate protamine sulfate# S-adenosyl methionine Sodium sulfate Sodium thiosulfate# taurine (IV) sulfate zinc sulfate# TraceCopper gluconate Iodine potassium iodide# Iron (II) fumarate (II) sulfate# Selenium selenate selenite Zinc acetate L-aspartate L-carnosine gluconate oxide proteinate zinc sulfate# UltratraceChromium (III) picolinate (III) chloride Fluorine fluoride# monofluorophosphate Lithium aspartate carbonate orotate Vanadium (IV) sulfate #WHO-EM ‡Withdrawn from market Clinical trials: †Phase III §Never to phase III vteElements in biologyElements Sodium in biology Magnesium in biology Potassium in biology Calcium in biology Manganese in biology Iron in biology Cobalt in biology Copper in biology Zinc in biology Selenium in biology Molybdenum in biology Iodine in biology Arsenic biochemistry Biological aspects of fluorine CHONPS (Core six elements) Carbon Hydrogen Oxygen Nitrogen Phosphorus Sulfur Deficiencies Chromium Copper Iron Iodine Potassium Manganese Molybdenum Sodium Selenium Zinc Toxicity Argyria (Silver) Arsenic poisoning Beryllium poisoning Acute beryllium poisoning Berylliosis Chlorine gas poisoning Chromium toxicity Cobalt poisoning Copper toxicity Cadmium poisoning Fluoride toxicity Halotolerance Iron poisoning Iron overload Lead poisoning Lithium toxicity Mercury poisoning Metal toxicity Nickel allergy Oxygen toxicity Selenium toxicity Thallium poisoning Tin poisoning Toxic hey metal Zinc toxicity Related Composition of the human body Lithium (medication) Mineral (Essential element) Soil salinity Uranium in the environment Health effects of radon Authority control databases InternationalGNDNationalUnited StatesIsraelOtherYale LUX