The Jacksonville Jaguars trel west to face the San Francisco 49ers on Sunday, Sept. 28, at Levi’s Stadium for a Week 4 clash.
Jacksonville is off to a 2–1 start under new head coach Liam Coen, fresh off a Week 3 win over the Houston Texans.
San Francisco sits at 2–0 and clearly operates at a higher level when Brock Purdy is steering the offense, but Mac Jones has been holding the fort in Purdy's absence.
The 49ers are preparing to get Brock Purdy back under center after a two-game absence, assuming he clears the practice week without setbacks. And truthfully, San Francisco may he little choice but to lean on him, with Mac Jones sidelined by a knee injury.
San Francisco 49ers vs Jacksonville Jaguars kick-off time
NFL - NFLLevi's StadiumThe 49ers and Jaguars will meet in Week 4 of the NFL season at Levi's Stadium in Santa Clara, California, on Sunday, September 28, starting at 4:05 pm ET.
Team news & squadsSan Francisco 49ers team newsThe 49ers he been dealt a brutal hand on the injury front, and it feels like every week brings another gut punch. George Kittle is parked on IR with a hamstring issue, Brandon Aiyuk is still grinding his way back from that nasty ACL/MCL tear, and the offensive line has taken its own hits with Ben Bartch and Spencer Burford sidelined.
And just when it looked like things couldn’t get worse, they did. The franchise cornerstone himself, Nick Bosa, tore his ACL against Arizona and is out for the year. That’s the kind of blow that shakes the foundation of a defense—and the locker room.
On the flip side, there’s been a surprising lifeline under center. Mac Jones, thrust into the spotlight, has managed the chaos with steady hands, going 53-of-80 for four touchdowns against only one pick. He's nursing an injury of his own, officially questionable, but if he’s cleared, we could be in for a fascinating twist: Jones lining up across from his old team.
There is some light peeking through, though. Brock Purdy is gearing up for a return, slated to grab some first-team reps in practice this week after missing time with a toe injury. Shanahan says it'll be limited work, but if Purdy is trending back, it could be just the spark this battered Niners squad needs.49ers injury news: Nick Bosa – out , George Kittle – out , Brandon Aiyuk – out , Mac Jones – questionable , Brock Purdy – questionable , Jauan Jennings – questionable , Jordan Watkins – questionable , CJ West – questionable , Mykel Williams – questionable , Renardo Green – questionable
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Trevor Lawrence was once touted as the NFL’s next superstar, but the reality hasn’t quite matched the hype. Sure, there he been flashes—none bigger than that dramatic playoff comeback against the Chargers—but the consistency just hasn’t been there. This season has been more of the same.
Through three games, he's posted 671 yards with four touchdowns and four picks, and his decision-making has looked shaky at best. Right now, he feels like a quarterback on the verge of another rough outing. This upcoming matchup against a relentless 49ers defense, despite a few injury setbacks, will be one of his toughest early-season tests.
Brenton Strange and Dyami Brown he combined for 253 receiving yards and a single touchdown, while Brian Thomas Jr. has hauled in seven catches of his own. On the ground, Jacksonville is churning out an impressive 141.7 rushing yards per game, paced by Tris Etienne Jr., who’s already piled up 270 yards and a score.
Defensively, the Jaguars are giving up just 17 points and 292 total yards per outing. Foyesade Oluokun anchors the unit with 23 tackles, Tron Walker has logged two sacks, and Jourdan Lewis has snagged a pair of interceptions.
Jaguars injury news: Wyatt Milum – questionable , Dyami Brown – questionable
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The Texans vs Titans game in Week 4 of the 2025 NFL season will be broadcast live on FOX. Fans can catch the coverage onFubo (Try for free today!).
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Bypass regional blackouts with ExpressVPNSign upHow to buy 49ers vs Jaguars ticketsThe showdown between the 49ers and the Jaguars is set for Levi's Stadium in Santa Clara, California, a venue that packs in up to 68,500 fans and promises a fiery atmosphere on game day.
Tickets are already up for grabs on StubHub, with entry starting at $386. From there, prices climb through the tiers — $300, $400, $500, $600, $700, $800, $900, $1,000, and stretching all the way into the premium ranges of $2,000, $3,000, $4,000, $5,000, $6,000, and topping out at $10,406 for the best seats in the house.
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49ers vs Jaguars Fantasy FootballThrough three weeks, Trevor Lawrence (14.7 projected W4 fpts) still hasn’t cracked QB1 territory, finishing QB24, QB15, and QB28. That’s not exactly what fantasy managers signed up for. His first real test against a defense worth its salt came against Houston last week—and the results weren’t pretty. Lawrence hit on just half of his throws, eraging a measly 5.5 yards per attempt.
On the season, he's completing only 55.8% of his passes, the second-worst mark in the league, barely ahead of Cam Ward. At this point, Lawrence is sitting squarely in QB2 land for Week 4, and unless something clicks, that's where he'll stay.
The 49ers, meanwhile, he their own drama. Losing Nick Bosa for the year is a backbreaker. We saw last season how ordinary this defense looked without him, and his absence will test just how sturdy this unit really is.
The quarterback situation is another wrinkle. Brock Purdy (17.6 projected W4 fpts) logged reps in practice most of last week and is inching closer to a return. In Week 1, he posted 16.8 fantasy points (QB16), connecting on 26 of 35 throws (74.3%) for 277 yards, two touchdowns, and a pair of picks. Given the injury chaos around him and a tough Seattle defense, that was a respectable outing—enough to show he’s at least got a safe fantasy floor. If Purdy suits up, he's in the fringe QB1 mix, especially if Jauan Jennings is healthy enough to go.
No matter who's under center, though, the 49ers' sure thing is still Christian McCaffrey (17.6 projected W4 fpts). He's been ridiculous to start the year—fourth in the league in receiving yards across all positions, tied with Dante Adams and ahead of Justin Jefferson. Let that sink in. Add in his production on the ground (14th in rushing yards league-wide), and it’s hard to imagine a more complete fantasy weapon. Put simply, CMC is matchup-proof and remains the crown jewel at running back.
49ers vs Jaguars Game PredictionsThis matchup has all the makings of a sneaky gem on this week's NFL slate. The Jacksonville Jaguars he built their early-season success on two pillars: a ball-hawking defense that sits atop the league with nine takeaways, and Liam Coen's revamped rushing attack, which is churning out 141.7 yards per game at an impressive 5.1 yards a pop.
But here comes the real measuring stick. Jacksonville's defense is about to stare down its toughest assignment of the year. Signs point to Brock Purdy suiting up, and even if he's not at 100 percent, and even if his supporting cast is banged up, he's still a bigger headache than the likes of Bryce Young, Jake Browning, or Houston's current offense.
My gut says the Jags finally get burned this week. Don't be shocked if Purdy dials up a couple of haymakers downfield, two of them, at least, landing in the hands of Ricky Pearsall. Expect a low-scoring scrap with neither side lighting up the scoreboard. Something like 20-14 feels about right, even though Jaguars are much healthier at the most important position.
49ers vs Jaguars Betting OddsSpread
Jaguars +3 (-102)
49ers -3 (-118)
Moneyline
Jaguars: +154
49ers: -185
Total
47.5 (Over -105/Under -115)
Form
SF-FormSan Francisco 49ers
16
-
15
Arizona Cardinals
W
New Orleans Saints
21
-
26
San Francisco 49ers
W
Seattle Seahawks
13
-
17
San Francisco 49ers
W
San Francisco 49ers
30
-
23
Los Angeles Chargers
W
Las Vegas Raiders
19
-
22
San Francisco 49ers
W
JAX-FormJacksonville Jaguars
17
-
10
Houston Texans
W
Cincinnati Bengals
31
-
27
Jacksonville Jaguars
L
Jacksonville Jaguars
26
-
10
Carolina Panthers
W
Miami Dolphins
14
-
6
Jacksonville Jaguars
L
New Orleans Saints
17
-
17
Jacksonville Jaguars
D
Head-to-Head RecordSFLast 5 matches
JAX5
Wins
0
Draws
0
Wins
Jacksonville Jaguars
3
-
34
San Francisco 49ers
Jacksonville Jaguars
10
-
30
San Francisco 49ers
San Francisco 49ers
44
-
33
Jacksonville Jaguars
Jacksonville Jaguars
10
-
42
San Francisco 49ers
San Francisco 49ers
20
-
3
Jacksonville Jaguars
Useful links49ers 2025 NFL schedule: TV channel, livestream & where to watch the gamesJaguars 2025 NFL schedule: TV channel, livestream & where to watch the gamesHow to watch and live stream NFL football for free and without cable2025 fantasy football rankings: Running back (RB) | Wide receiver (WR) | Tight end (TE) | Quarterback (QB)